Insomnia is one of the most common depression symptoms. However, there is limited scientific evidence that side effects go away or that they go away after a specific time after stopping the medication. However, insomnia remains a common issue. And Lexapro may help ease the sleeplessness that many people with depression experience.īy regulating serotonin levels, Lexapro could even improve sleep in some people. Some people may find that insomnia improves over time. Serotonin is also a precursor to melatonin, a hormone that regulates a person’s sleep-wake cycle. This may explain why people either have insomnia or feel sleepy after taking an SSRI. That said, if high serotonin acts on a certain part of the brain, such as the dorsal raphe nucleus, it can also induce sleep. One theory is that an SSRI, such as Lexapro, can increase serotonin and induce wakefulness contributing to the insomnia. In people with depression, insomnia is already a common symptom, which may partially be due to low serotonin from depression. Serotonin levels play a role in determining sleep or inducing insomnia. The relationship between serotonin, the brain, and sleep is complex, with many factors to consider. Studies on the topic have reached mixed - and sometimes contradictory - results. While researchers know Lexapro raises serotonin levels in the brain, they do not fully understand how this might affect sleep. People in the placebo group do not receive an active form of the drug. In one trial, 9% reported insomnia on Lexapro, compared to 4% on placebo. What is the link between Lexapro and insomnia?Ĭlinical trial data show that people using Lexapro were more likely to report insomnia.
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